Test selection
We help match the clinical indication, sample type, and testing method before the order is placed.
For physicians
We help match the clinical indication, sample type, and testing method before the order is placed.
We clarify tube, tissue, tumor-content, and shipment needs to reduce avoidable rejection or delay.
Reports are reviewed with attention to clinical context, actionability, and limitations.
We support next-step interpretation, family testing questions, and additional testing decisions.
Ordering resources
Five-step process from clinical question to report — including how AC fits into your workflow.
View ordering guideTube types, tissue requirements, storage, and shipping instructions by test category.
View specimen guideAll available tests organised by clinical indication — oncology, hereditary, prenatal, rare disease, and more.
Browse test menuVerified physicians can access requisition forms, consent templates, and results through the secure client portal.
Open client portalClinical leadership
Omar Issa
MD — Medical Director, Advanced Consensus
Medical Director, Advanced Consensus
View full profileEvery report that leaves Advanced Consensus has been reviewed by Dr. Issa — I take personal responsibility for how each result is interpreted and communicated.
Selected cases
The challenge
A patient with a strong personal and family history suggestive of hereditary cancer had previously received limited genetic testing without a clear result. The treating physician requested support to review the case and select a broader panel.
What interpretation changed
Expanded testing identified a clinically significant pathogenic variant, changing the patient's risk assessment and enabling cascade testing for family members. The case moved from uncertainty to a clear prevention and surveillance plan.
The challenge
A patient with advanced solid tumour disease required molecular profiling to identify potential targeted therapy options. Available tissue was limited and the team needed guidance on the most suitable test and specimen requirements.
What interpretation changed
Comprehensive tumour profiling identified actionable alterations with therapeutic relevance. The report supported prioritisation of treatment options and eligibility assessment for targeted therapy or clinical trial pathways.
The challenge
A child with unexplained developmental and medical features had undergone multiple evaluations without a definitive diagnosis. The clinical team requested support in selecting the most appropriate genomic test.
What interpretation changed
Exome/genome-based testing with phenotype-driven interpretation identified a molecular diagnosis, enabling the treating team to explain the condition, guide clinical follow-up, and provide accurate recurrence-risk counselling for the family.
The challenge
A patient's genetic report included a variant of uncertain significance, creating uncertainty for both the clinician and the family about appropriate next steps.
What interpretation changed
Review of variant classification, available evidence, phenotype correlation, and inheritance pattern confirmed the variant should remain classified as uncertain — preventing overinterpretation and helping the physician communicate why management should not be based on the variant alone.
The challenge
A hospital wanted to offer advanced molecular and genetic testing but did not have local access to every specialised assay needed by its clinical teams.
What interpretation changed
A structured pathway for test selection, sample coordination, international laboratory access, report review, and clinician support allowed the hospital to expand its precision medicine offering while maintaining a local medical interface.
The challenge
A couple undergoing reproductive genetic evaluation received a result that required careful explanation. The clinical meaning of the finding and appropriate next steps were not immediately clear.
What interpretation changed
Report review and clinical framing gave the couple a clear understanding of the finding, its limitations, and appropriate next steps — reducing confusion and supporting informed reproductive decision-making.
Cases are de-identified and shared for illustration only; they do not represent guaranteed outcomes and are not medical advice. Testing is ordered and interpreted in consultation with a qualified physician.
Case discussion
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